Reaction of dATP with N-methyl-N-nitrosourea in vitro.
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منابع مشابه
Some effects of treatment of hen erythrocytes in vitro with N-methyl-N-nitrosourea.
Studies have been made of the effect of N-methyl-N-nitrosourea on hen erythrocytes in vitro. These were done to find whether the highly condensed state of the chromatin and the very low metabolic activity of these cells would affect the extent of methylation of the DNA and chromatin proteins and the persistence of any methylation sites in these macromolecules with time after treatment. Also, th...
متن کاملMorphogenesis of neoplasms induced in the hamster trachea with N-methyl-N-nitrosourea.
The tracheas of 95 male Syrian golden hamsters were locally exposed to a flowing stream of a 1% solution N-methyl-N-nitrosourea using a specially designed cannula at weekly intervals for 15 weeks. Animals were killed at specified times from 9 through 27 weeks following the first dose. Epithelial flattening was observed in over 90% of the tracheas throughout the study, but the proportion of the ...
متن کاملDNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Dideoxy chain-termination DNA sequencing was used to determine the specific DNA base changes induced after in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU) using the xanthine guanine phosphoribosyltransferase (gpt) gene as the genetic target. The resultant mutation spectra were compared with the levels of O6-alkylguanine and O4-alkylthymidine ...
متن کاملMetabolism of retinol and retinoic acid in N-methyl-N-nitrosourea-induced mammary carcinomas in rats.
This study was conducted to examine the in vivo uptake and metabolism of natural retinoids by N-methyl-N-nitrosourea-induced mammary carcinomas. In this study, endogenous retinol and retinyl esters were present in normal mammary epithelial cells, but were undetectable in N-methyl-N-nitrosourea-induced mammary carcinomas in rats as determined by high-pressure liquid chromatography. No difference...
متن کاملPreventive effect of Oenothera rosea on N-methyl-N-nitrosourea-(NMU) induced gastric cancer in rats
Background Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated. Aim The main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)44558-3